New Function of CDC13 in Positive Telomere Length Regulation
نویسندگان
چکیده
منابع مشابه
Insights into Cdc13 dependent telomere length regulation
Cdc13 is a single stranded telomere binding protein that specifically localizes to the telomere ends of budding yeasts and is essential for cell viability. It caps the ends of chromosomes thus preventing chromosome end-to-end fusions and exonucleolytic degradation, events that could lead to genomic instability and senescence, the hallmark of aging. Cdc13 is also involved in telomere length regu...
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Budding yeast telomerase is mainly activated by Tel1/Mec1 (yeast ATM/ATR) on Cdc13 from late S to G2 phase of the cell cycle. Here, we demonstrated that the telomerase-recruitment domain of Cdc13 is also phosphorylated by Cdk1 at the same cell cycle stage as the Tel1/Mec1-dependent regulation. Phosphor-specific gel analysis demonstrated that Cdk1 phosphorylates residues 308 and 336 of Cdc13. Th...
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15 صفحه اولRole of TERRA in the Regulation of Telomere Length
Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA, a long non-coding RNA, part...
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Distinct Functions of POT1 in Telomere Protection and Length Regulation by Katharine Specchio Barrientos Department of Pharmacology and Cancer Biology Duke University Date: November 20th, 2008 Approved: ___________________________ Christopher M. Counter, Ph.D., Supervisor ___________________________ Shawn Ahmed, Ph.D. ___________________________ Ann Marie Pendergast, Ph.D. _____________________...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2001
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.21.13.4233-4245.2001